Predictive and Mechanistic Toxicology

Predictive and mechanistic toxicology assists our clients in defending existing products by providing expert opinions, based on the latest scientific knowledge, and prospectively evaluating the potential of new chemical entities, based on chemical structure and experimental studies, to affect selected target organ systems for early compound screening and selection:

• In silico toxicology
  Prediction of toxicological potential /
  structure alerts
  (Quantitative) Structure activity relationship
  (TOPKAT, DEREK)
• Metabolic activation / bioavailability
• Covalent binding / dosimetry
• Oxidative stress
• Endocrine toxicology
• Enzymology