Genotoxicity and Cell Biology

Harlan Laboratories offers a complete range of genotoxicity testing to enter clinical trials as well as many screening versions of these test systems and several exploratory techniques.

Genotoxicity testing

• Ames, HPRT, mouse lymphoma test
• Chromosome aberration test in vitroand in vivo
• Micronucleus test in vitro and in vivo
• UDS in vitro and in vivo
• Comet assayinvitro and invivo
• DNA binding / adducts

Alternative Toxicology/ Cell-based assays

• Cytotoxicity
• Photo-cytotoxicity
• Photo-mutagenicity
• Cell transformation assay (SHE / Balb/c 3T3 / Bhas)
• BCOP, REET, EpiOcular – eye irritation
• Human skin models – skin irritation / corrosivity
•  Local nymph node assay
• In vitrometabolism – metabolic profiling / species specific kinetics
• Barrier systems – blood-brain, skin, intestinal uptake
• Embryonic mouse stem cell test – reproductive toxicity