Predictive and
mechanistic toxicology assists our clients in defending existing
products by providing expert opinions, based on the latest
scientific knowledge, and prospectively evaluating the potential of
new chemical entities, based on chemical structure and experimental
studies, to affect selected target organ systems for early compound
screening and selection:
- In silico toxicology
- Prediction of toxicological potential /
structure alerts - (Quantitative) Structure activity
relationship
(TOPKAT, DEREK)
- Metabolic activation / bioavailability
- Covalent binding /
dosimetry
- Oxidative stress
- Endocrine toxicology
- Enzymology
- Biomarkers