Safety Pharmacology Flyer
Harlan Laboratories can offer all studies indicated in the
ICH S7A and ICH S7B guidelines, which specifies a core battery of
tests to be performed on pharmaceuticals before the first
administration to volunteers in phase I trials.
Central nervous system
- Modified Irwin screen
- Functional observation battery
Cardiovascular system
- Telemetered animals
- Anaesthetised animals
- In vitro HERG-1 assay
- Guinea pig papillary muscle
Respiratory system
- Can be performed as part of telemetry or in a separate
study