Environmental fate encompasses distribution and dissipation processes in important compartments of the environment (soil, water, air) and provides data necessary for the calculation of Predicted Environmental Concentrations (PEC). This also includes the characterization and identification of unknown metabolites.
Harlan Laboratories performs the full range of environmental fate studies (laboratory and field) under international test guidelines and full GLP compliance. We have extensive experimental and regulatory experience with a wide range of products including agrochemicals, industrial chemicals, biocides, and human and veterinary pharmaceuticals.
In addition, we provide cutting edge environmental modeling services, ranging from model-based data evaluation via highly standardized environmental exposure assessments to custom scenario development for PEC calculations.
Biotic Systems
- Water sediment studies OECD 308
- Soil metabolism studies OEDC 307
- Aerobic degradation OECD 309
Abiotic Systems
- Adsorption/desorption OECD 106, OPPTS 835.1110, OPPTS 835.1220, with soil, sludge or sediment
- Photolysis in buffer OECD 316, OPPTS 835.2210
- Soil photolysis OPPTS 835.2410
- Hydrolysis studies OECD 111, simulated processing OECD 507
Analytics and Metabolite Identification
- Radioisotopes 14C, 3H, 35S
- Radio-HPLC, TLC
- LC-MS
- Ionization: ESI, APCI, APPI
- Metabolite identification by co-chromatography, LC-MS, NMR
Instrumentation: Bruker MaXis TOF-MS for accurate mass
Modeling
- FOCUS and European national pesticide PEC calculations
- PEC calculations under the biocidal product directive
- Industrial chemicals (REACH) and pharmaceuticals (EMEA)
With additional services in the fields of PK/TK, livestock and plant metabolism, Harlan Laboratories covers all areas of metabolism testing. In addition, Harlan Laboratories offers extensive regulatory expertise, including risk assessment for chemicals, as well as agrochemicals and human and veterinary pharmaceuticals.