Pharmacokinetics & Toxicokinetics

The Bioanalytics & PK/TK department of Harlan Laboratories consists of scientists with extensive experience in data analysis and the ability to deliver results in a timely manner. Our focus on Modeling & Simulation facilitates study design, challenging drug development and decision-making processes.

Pharmacokinetics & Pharmacodynamics

• Non-compartmental PK
• Compartmental PK/simulation
• PD and PK/PD modeling
• Interpretation and reporting

Toxicokinetics

• Incrementing doses (dose-dependency)
• Repeat doses (time-dependency)
• Other cofactors (gender, strain, etc.)
• Metabolite ratios

Additional Services

• Study design
• Deconvolution
• Scaling techniques (interspecies and first-in-man)
• PBPK and reduced PBPK
• Clinical PK
• Drug/disease models

In close cooperation with scientists in our Toxicology and Drug Metabolism departments, our team provides an integrated platform for pharmacokinetics, with 40 percent of projects focusing on small molecules and biologics. Analyses are carried out with WinNonLin™ and BerkeleyMadonna^® software.

Harlan Laboratories supports full packages or can deliver flexible, stand-alone PK work for multisite studies.