Literature
Harlan Laboratories supports our clients with ADME assays and
programs in all phases of the discovery and development pipeline.
These include Lead Optimization programs by in vitro and
in vivo PK screening, as well as PK or toxicokinetic
profiling, mass balance and distribution studies. Metabolite
profiling and identification provides a rationale for the selection
of animal species in toxicology studies.
Services
- Mass balance studies (absorption and excretion)
- Pharmaco- and toxicokinetic profiling
- Bioavailability and bioequivalence
- Tissue distribution
- Quantitative whole body autoradiography
- Biliary excretion
- Placental and milk transfer
- Protein binding, blood/plasma partition
- CYP-profiles, drug-drug interactions
- Metabolism in vitro and in vivo
- Metabolite profiling, characterisation and identification
- Dermal penetration in vitro and in vivo
- Radio-analytical support of clinical trials