Pharmacology studies, which include safety pharmacology, pharmacodynamics and efficacy studies, contribute to the risk assessment of NCEs in pharmaceutical development by identifying undesirable pharmacodynamic properties before the first administration to man
(Phase I). These studies can also be used to evaluate adverse effects observed in toxicology or early clinical trials, and to investigate the mechanism(s) underlying them.
Services that Harlan Laboratories offer can be performed in the species of choice with any of the standard routes of administration.
- Central nervous system pharmacology
- Cardiovascular pharmacology
- Respiratory function pharmacology
- Gastrointestinal pharmacology
- Renal and liver function
- Autonomic nervous system
- Inflammation
Additionally, we offer services in disease animal models within the following areas:
- Autoimmunity
- Diabetes
- Tissue repair
- Osteoporosis and bone repair
- Tumor models
- Metabolic disorders and obesity models