Athymic Nude Mice

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This nude mouse was derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland. This immunodeficient model was originally thought to be a Balb/c congenic, but was later reported by NCI to be outbred.

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Athymic Nude Mice - Euro

Additional Available Data

Health Monitoring Reports
Location Report
Blackthorn - Isolator 170 Download PDF
Blackthorn - Isolator 172 Download PDF
Hillcrest - Isolator 203 Download PDF
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AthymicNude_MutantMice

Characteristics

  • Coat: Albino
  • Litter Average: 7
  • The nu allele on chromosome 11 is an autosomal recessive mutation
  • Dysfunctional rudimentary thymus
  • Phenotypically hairless (sparse, intermittent hair growth possible)
  • T-cell deficient
  • B-cells function normal
  • No generation of cytotoxic effector cells
  • No graft versus host response
  • Foxn1nu/Foxn1+ heterogygotes do not show partial expression of the nu phenotype

Research Use

  • Oncology
  • Transplantation
  • Tumor cell growth
  • Immunology
  • Autoimmune disease
  • Antibody production
  • Sentinel model - Heterozygous Hsd:Athymic Nude-Foxn1nu/Foxn1+
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