BALB/c Nude Mice

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Produced in

This nude mouse was derived from Institute of Animal Genetics, Edinburgh, UK, to Laboratory Animals Centre, Carshalton, UK, to GD Searle, High Wycombe, UK, to Olac (now Harlan Laboratories) in 1978.

Additional Available Data

Health Monitoring Reports
Location Report
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BALB_cNude_MutantMice

Characteristics

  • Coat: Albino
  • The nu allele on chromosome 11 is an autosomal recessive mutation
  • Dysfunctional rudimentary thymus
  • Phenotypically hairless (sparse, intermittent hair growth possible)
  • T-cell deficient
  • B-cells function normal
  • No generation of cytotoxic effector cells
  • No graft versus host response
  • Foxn1nu/Foxn1+ heterogygotes do not show partial expression of the nu phenotype

Research Use

  • Oncology
  • Transplantation
  • Tumor cell growth
  • Immunology
  • Autoimmune disease
  • Antibody production
  • Sentinel model - Heterozygous BALB/cOlaHsd-Foxn1nu/Foxn1+
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