Diabetic (db/db) Mice

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Strain

Produced in

The Diabetic mutant mouse originates from the Dunn Nutritional Laboratory, Cambridge, United Kingdom; to Olac, United Kingdom, in 1979; to Harlan Laboratories, United States, in 2000.

Related Genotypes (lean animals):          

  • Heterozygous Nomenclature:     
    • BKS.Cg-Dock7m +/+ Leprdb/OlaHsd (Black, Lean)
  • Wild type Nomenclature:         
    • BKS.Cg-Dock7m  +/Dock7m +/OlaHsd (Misty, Lean)

Our breeding scheme maintains Dock7m and Leprdb in repulsion.  These genes are closely linked; however, recombination could occur. Our mice are most likely nonrecombinants, but they have not been tested.  Genetic testing is required to distinguish heterozygotes from wild type animals.

DownloadGrowth Curve
Diabetic Mutant Mice - US

Additional Available Data

  • Hematology
  • Clinical Chemistry
  • 12-week growth
  • Glucose tolerance test
Health Monitoring Reports
Location Report
Indianapolis, IN - 217 Download PDF
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Diabetic(db_db)_MutantMice

Characteristics

  • Coat: Black or misty
  • Leprdb is an autosomal-recessive mutation on chromosome 4
  • Obesity expressed at 4-5 weeks of age
  • Elevation of plasma insulin demonstrated at 10-14 days
  • Hyperglycemia expressed at 4-8 weeks of age
  • Polyphagia
  • Proteinuria
  • Glycosuria
  • Polyuria/Polydipsia
  • Hyperinsulinemia despite severe depletion of pancreatic islet insulin-producing B-cells
  • Leptin receptor deficient

Research Use

  • Diabetes, Type 2
  • Peripheral neuropathy
  • Myocardial disease
  • Immunodeficiency
  • Immunology
  • Metabolism
  • Obesity
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