NOD.SCID Mice

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The NOD.SCID mutant mouse was received by National Cancer Institute, Frederick, Maryland, in 2004. Harlan acquired from National Cancer Institute in 2006.

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NOD.SCID Mutant Mice - US

Additional Available Data

Health Monitoring Reports
Location Report
Indianapolis, IN - 282I Download PDF
Livermore, CA - 237I Download PDF
Madison, WI - 203I Download PDF
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Characteristics

  • Coat: Albino
  • Autosomal recessive, single nucleotide polymorphism with Prkdc gene on chromosome 16
  • Severe combined immunodeficiency affecting T- and B-lymphocyte development
  • Natural Killer (NK) cell, macrophage and granulocyte numbers and function are reduced
  • As SCID mice age, a variable percentage become "leaky" from spontaneous development of functional T- and B-lymphocytes
  • Highly susceptible to opportunistic viral and bacterial infection
  • Development of autoimmune diabetes does not occur due to severe combined immunodeficiency
  • Spontaneous thymic lymphomas

Research Use

  • Oncology
  • Transplantation
  • Tumor cell growth
  • Immunology
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