SCID/Beige Mice

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Strain

Produced in

Harlan acquired the SCID beige mutant mouse from the Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA, in 1991.

Additional Available Data

Health Monitoring Reports
Location Report
Indianapolis, IN - 282I Download PDF
Madison, WI - 203I Download PDF
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Characteristics

  • Coat: Albino
  • Autosomal-recessive, single-nucleotide polymorphism within Prkdc gene on chromosome 16
  • Autosomal-recessive beige mutation on chromosome 13
  • Severe lymphopenia
  • Diminished Natural Killer (NK) cell activity relative to other SCID models
  • Rudimentary thymus
  • Highly susceptible to opportunistic viral and bacterial infection

Research Use

  • Oncology
  • Teratology
  • Transplantation
  • Tumor cell growth
  • Immunology
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