Zucker Obese Rats

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Stocks

Produced in

This Zucker rat was derived from a colony obtained in 1992 from Hoffmann-La Roche, Nutley, New Jersey.

Additional Related Genotypes (lean animals)

  • HsdHlr:ZUCKER-Leprfa/Lepr+ (Heterozygous)
  • HsdHlr:ZUCKER-Lepr+ (Wild Type)

Genetic testing is required to determine Leprfa/Lepr+ or Lepr+ genotype.

DownloadGrowth Curve
Zucker Obese (HsdHlr) Mutant Rat - US

Additional Available Data

  • Hematology
  • Clinical Chemistry
  • 12-week growth
Health Monitoring Reports
Location Report
Indianapolis, IN - 202C Download PDF
Livermore, CA - 237 Download PDF
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ZuckerObese_MutantRats

Characteristics

  • Coat: Black, brown, brown/white, black/white
  • Leprfa/Lepr+heterozygotes do not show partial expression of fa phenotype
  • fa is an autosomal-recessive mutation on chromosome 5
  • Exhibit obesity at 4 to 5 weeks of age
  • Animals have not been selectively bred to induce hyperglycemia
  • Insulin resistant
  • Adipocyte hypertrophy and hyperplasia
  • Hyperphagia
  • Muscle atrophy
  • Hyperlipemic
  • Hypercholesterolemia
  • Hyperinsulinemia

Research Use

  • Genetic obesity
  • Diabetes, Type 2
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