Research Models and Services
- Areas of Research
  - Oncology

Rodent Models for Oncology Research

Global Availability

Harlan Laboratories offers a breadth of oncology rodent models. Our immunodeficient rodent models
have proven performance in tumor uptake and growth.

We offer an extensive online database of peer-reviewed publications across major cancer cell lines.
Click here to use our new cell line reference tool. It will help you identify the right model for your
tissue of interest and the cell line.

For additional details on Harlan's rodent models for oncology, download our Oncology Brochure
or contact us.

Immunodeficient Rodent Models

Harlan offers a line of nude mice, SCID mice, and nude rats to support your research needs. Each rodent model has been characterized in a comparative table to help facilitate model selection. Our immunodeficient rodent models have proven performance in tumor uptake and growth.


Model	Nomenclature	Hair	T Cells	B Cells	NK Cells
Nude Mice
Beige Nude XID	Hsd:NIHS-Lyst^bgFoxn1^nuBtk^xid	No	Nonfunctional	Impaired	Impaired
Athymic Nude	Hsd:Athymic Nude-Foxn1^nu	No	Nonfunctional	Functional	Functional
BALB/c Nude	BALB/cOlaHsd-Foxn1^nu	No	Nonfunctional	Functional	Functional
NMRI Nude	HsdCpb:NMRI-Foxn1^nu	No	Nonfunctional	Functional	Functional
MF1 Nude	HsdOla:MF1-Foxn1^nu	No	Nonfunctional	Functional	Functional
SCID Mice
SHrN™ (emerging model)	NOD.Cg-Prkdc^scidHr^hr/NCrHsd	No	Nonfunctional	Nonfunctional	Impaired
NOD.SCID	NOD.CB17-Prkdc^scid/NCrHsd	Yes	Nonfunctional	Nonfunctional	Impaired
SCID/Beige	C.B-17/IcrHsd-Prkdc^scidLyst^b	Yes	Nonfunctional	Nonfunctional	Impaired
SCID	C.B-17/IcrHsd-Prkdc^scid	Yes	Nonfunctional	Nonfunctional	Functional
SCID	C.B-17/IcrHan™Hsd-Prkdc^scid	Yes	Nonfunctional	Nonfunctional	Functional
SCID	BALB/cJHan™Hsd-Prkdc^scid	Yes	Nonfunctional	Nonfunctional	Functional
Nude Rat
Athymic Nude	Hsd:RH-Foxn1^rnu	No	Nonfunctional	Functional	Functional

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Immunocompetent Rodent Models

Harlan offers a full line of spontaneous and inducible tumor models in addition to traditional rodent models.

Spontaneous and Inducible Models


Model	Nomenclature	Research Use
Mice
A/J	A/JOlaHsd	Spontaneous lung tumors
AKR	AKR/OlaHsd	High incidence of spontaneous leukemia
B6D2F1	B6D2F1/Hsd B6D2F1/JRccHsd B6D2F1/OlaHsd	Chemical induction of bladder tumors
C3H	C3H/HeNHsd	Spontaneous hepatocellular and mammary tumors
CBA	CBA/CaOlaHsd CBA/JCrHsd	Susceptible to chemical induction of myeloid leukemia; hepatoma in males; mammary tumors in females
C57BL/6	C57BL/6JOlaHsd C57BL/6JRccHsd C57BL/6NHsd	Accepts murine B16F10 melanoma grafts
SJL	SJL/JCrHsd SJL/JOlaHsd	High incidence of reticulum cell sarcoma (comparable to Hodgkin’s), leukemia
Rats
ACI	ACI/SegHsd	Spontaneous testicular and prostate cancer in aged males; females highly susceptible to estrogen-induced mammary tumors; spontaneous pituitary tumors in both sexes
Brown Norway	BN/RijHsd BN/SsNOlaHsd	Spontaneous bladder tumors; susceptible to chemical induction of myeloid leukemia
Wistar Furth	WF/NHsd	High incidence of spontaneous leukemia and pituitary tumors

Traditional Models


Model	Nomenclature	Research Use
Mice
BALB/c	BALB/cAnNHsd BALB/cJRccHsd BALB/cOlaHsd	Mammary tumors in aged mice; capable of monoclonal antibody production with injection of pristane and hybridoma cell line
Rats
Sprague Dawley®	Hsd:Sprague Dawley® SD®	Chemical tumor induction; carcinogenicity, toxicology; spontaneous tumors
Fisher 344	F344/NHsd F344/NCrHsd	Various spontaneous tumors in aged rats; carcinogenicity

Model	Immune Characteristics						Reference
	T Cells	B Cells	NK Cells	APC cells, complement	Additional notes on immunophenotype	SCID Leakiness
SHrN*	Nonfunctional	Nonfunctional	Impaired function	Differentiation and functional defects in APCs; absence of circulating complement		Very Low	Characterization in Progress
NOD.SCID	Nonfunctional	Nonfunctional	Impaired function	Differentiation and functional defects in APCs; absence of circulating complement	Radiosensitive (<400Gy); high incidence of lymphoma	Low	Shultz, L.D. et al. (1995). J Immunol, 154:180-91. Prochazka et al. (1992). Proc Natl Acad SciU.S.A., 89:3290-4. Greiner, D.L. and Shultz, L.D. (1998). The use of NOD/LtSz-scid/scid mice in biomedical research. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer andOther Diseases. (Leiter E and Atkinson M, eds). Austin: RG Landes Company, pp 173-203.
SCID-beige	Nonfunctional	Nonfunctional	Impaired function	Functional deficits	Lytic activity of NK cells impaired without reduced cell population or cytokine production	Low	Mosier, D.E. et al. (1993). J Exp Med, 177:191-4. Thomsen, M. et al. (2008). Toxicol, 246:18-23.
SCID	Nonfunctional	Nonfunctional	Functional	Normal	Leaky phenotype dependent on genetic background; Radiosensitive (<400Gy)	High (BALB/c); Moderate (C3H, ICR)	Bosma et al. (1983). Nature, 301:527-30. Gibson, D.M. et al. (1989). Limited clonal diversity of serum immunoglobulin in leaky scid mice, pp 125-36. In: Current topics in microbiology and immunology: The scid mouse (Eds.): Bosma, M.J., Phillips, R.A., and Schuler, M.). New York: Springer-Verlag, Bosma, G. et al. (1988). J Exp Med,167:1016-33. Poole, T.W. (1996). Lab Animal, 25:29-32. Nonoyama , S. et al. (1993).J. Immunol., 150(9):3817-24. Bosma, M.J. (1992). Immunodeficiency Reviews, 3:261-76.
Beige-nude-XID*	Nonfunctional	Impaired function	Impaired function	Partially defective	Reduction in LAK activity; defect in lysosomal trafficking; Radiosensitive (<400Gy)	N/A	Jicha (1992). J Immunother, 11:19-29. Waggie, K.S. et al. (1992). Lab Anim Sci, 42:375-7.
Nude mouse*	Nonfunctional	Functional	Functional	Normal function	T cell precursors unaffected by mutation; some extrathymic functional T cells with age	N/A	Flanagan, S.P. (1966). Genet Res, 8:295-309. Teicher, B.A. (Ed.). (2002). Tumor models in cancer research. Totowa, New Jersey: Humana Press Inc. Croy, B.A. et al. (2001). Comp Med, 51(4):300-13. Gullino, P.M. et al. (1976). Inst Lab Animal Resources News, 19:5-19. Fogh, J. and Giovanella, B. (Eds.). (1978). The Nude Mouse in Experimental and Clinical Research. New York: Academic Press.
Nude rat*	Nonfunctional	Functional	Functional	Normal function		N/A	National Research Council. (Eds.). (1989). Immunodeficient Rodents: A Guide to Their Immunobiology, Husbandry, and Use. Washington, D.C.: National Academy Press. Vos, J.G. et al. (1980). Clin immunol and Immunopathol, 15:229-37. Schuurman , H. et al. (1992). ILAR, 34:1-12. Taubman, M.A. et al.(1983). Immunol, 49: 295-300.
Hairless/nude-animal does not produce full pelage. All models highly susceptible to opportunistic viral and bacterial infection*