SHrN™ Hairless NOD.SCID Mouse

A new option for improved oncology research outcomes.

Harlan Laboratories is pleased to announce the development of the inbred SHrNTM ("Shorn") Hairless NOD.SCID Mouse. The Shorn is a triple-immunodeficient model with distinct benefits, excellent for humanization and tumor xenografts.

 

SHrN Hairless NOD.SCID Mouse
FeaturesAdvantages
Hairless

Eliminates need to shave model, saving time and labor

Improved tumor imaging clarity

Improved observation of tumor growth

Severe Immunodeficiency

  • Deficient in T and B cells
  • NK cell functional deficit
  • No circulating complement
  • Decreased macrophage function
  • Decreased granulocyte function
  • Decreased dendritic cells

More immunocompromised than other hairless SCID models

Preliminary phenotyping results show promising advantages in cell uptake and tumor growth

Decreased leakiness compared to other SCID models

Enhanced acceptance and growth of cells for humization

InbredLess variability in research

Posters on this mouse model:

The SHrN™ scid hairless NOD mouse model: Development and characterization

Characterization of the Hairless NOD.SCID Mouse Model (SHrN™)

Additional Information:

For additional details regarding the characterization of this new model, contact us at technicalservices@harlan.com.

To receive updates on the development progress of this model, please complete the information request form below.

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