Atherogenic diets range from adding cholesterol and/or cholate
to a standard rodent feed, or using a purified diet (usually high
in fat) with various levels of cholesterol and/or cholate.
The type of atherogenic diet best for any given experiment is
dependent upon the animal model, the desired endpoint, and the
length of feeding. Contact us for more
information.
A few examples are given here, and more details follow
below.
TD.88137 Adjusted
Calories Diet (42% from fat)
TD.88051
Cocoa Butter and Purina Chow Diet
TD.90221
Cocoa Butter Diet with 75% Purina Mouse (5015)
TD.94059
5015, Cocoa Butter, Chol., etc. (excludes cholate)
TD.02028
Atherogenic Rodent Diet (1.25% Chol. & 0.5% Cholic Acid)
TD.01383
2018 + 2% Cholesterol
"Western"
Diet
TD.88137 is often referred to in the literature as
the "Western" Diet. This is a purified diet with 21% anhydrous
milkfat (butterfat), 34% sucrose, and a total of 0.2% cholesterol.
The formula originated with researchers at Rockefeller University,
and is widely used with ApoE deficient and other like models. There
are a number of modifications of TD.88137 with varying levels of
added cholesterol, and with customer supplied compounds. Contact us for
more information about TD.88137, modifications, or possible control
diets.
"Paigen"
Diet
This diet originated in the lab of Dr. Beverly Paigen with
the dilution of a very concentrated purified diet (containing 5%
cholesterol and 2% sodium cholate; sometimes referred to as the
Thomas-Hartroft diet) with a standard mouse breeder diet (PMI
5015); 1 part purified diet to 3 parts standard diet. The resulting
diet has 1.25% cholesterol and 0.5% sodium cholate. The literature
cites the use of this diet in C57Bl/6 mice and in genetically
modified mice. TD.88051 and
TD.90221 are Teklad product codes for this diet
(same formula). TD.94059 is a modification without
sodium cholate. There are also versions of this diet using a base
diet other than 5015. Contact us for more
information about these diets or modifications.
Standard diets with
added cholesterol
We have numerous formulas on file with varying levels of
cholesterol added to standard diets. TD.01383 is
one such example. Contact us with your
specific needs.
Atherogenic diets for
species other than rats and mice
Rabbits, hamsters, and swine are models used to study
cardiovascular disease. See
Rabbit Diets or
Other Species for information and formula examples, or contact
us.
For general information, please contact us at tekladinfo@harlan.com.
For technical questions, please contact us at askanutritionist@harlan.com.