B10.A-H-2^a Congenic Mice

Nomenclature: B10.A-H-2^a/OlaHsd

This strain is cryopreserved.  Please contact us at Harlancommunications@harlan.com or call Technical Service for assistance with revitalization and contract breeding of this model.

 B10 Congenic Mice Origin

• The B10.A-H2^a/OlaHsd congenic line was developed by Dr. Jack H. Stimpfling, The McLaughlin Research Institute, Montana, to GD Searle, High Wycombe. From GD Searle to OLAC (now Harlan Laboratories) in 1978.

B10 Congenic Mice Characteristics

• Coat: Black
• Inbred partner is C57BL/10Sn and the donor strain is A/WySn
• Differential histocompatibility locus H-2^a, due to H-2^kH-2^d crossover. 
• High immune response to ferritin in C57BL/10 and congenic lines B10.M, B10.D2, B10.BR and B10.A
• Mean survival 128 ± 4.1 weeks

Harlan Laboratories' Production

• We maintain on Teklad Global Diet 2018S within maximum security production facilities. 

References

1. Klein, J.  (1973).  List of congenic lines of mice. I. Lines with differences at alloantigen loci.  Transplantation, 15, 137-153.
2. Klein, J., Figuerora, F., David, C.S.  (1983).  H-2 haplotypes, genes and antigens:  Second listing.  II.  The H-2 complex.  Immunogenetics, 17, 553-596.

3. Smith, G.S., Walford, R.L.  (1977).  Influence of the main histocompatibility complex on aging in mice.  Nature, 270, 727-9.

4. Young, C.R., Deacon, N.J., Ebringer, A., Davis, D.A.L.  (1976).  Genetic control of the immune response to ferritin in mice.  J. Immunogen., 3, 199-205.