C57BL/6JOla & C57BL/6JRcc Inbred Mice

Nomenclature: C57BL/6JOlaHsd, C57BL/6JRccHsd

Black 6 Inbred Mice Origin

• C57BL/6JOlaHsd:  In 1974, from the Jackson Laboratory to Laboratory Animals Centre,Carshalton. To OLAC (now Harlan UK) in 1983. In 1997 to Harlan Laboratories in the Netherlands.
• C57BL/6JRccHsd:  In 1973, from the Jackson Laboratory to the Biological Research Laboratories-RCC Ltd. Füllinsdorf, Switzerland. In 2005, Harlan Laboratories obtained a breeding nucleus after acquisition of RCC Ltd.

Black 6 Inbred Mice Characteristics

• Coat: Black
• Litter average: 6.5
• Haplotype: H-2^b
• Low Spontaneous Tumor Incidence   
• 1-3% Incidence of Hydrocephalus
• High Alcohol Preference 
• Increased Levels of Protein Kinase C
• Microphthalmia & Anopthalmia
• C57BL/6JOlaHsd possess α-synuclein deletion
• C57BL/6JRccHsd subline does not carry the Nnt (nicotinamide nucleotide transhydrogenase) gene deletion

Black 6 Inbred Mice Research Use

• Aging
• Alcoholism
• Background for induced and genetically modified models
• Behavior and Learning studies
• Cardiovascular
• Diet induced obesity
• Drug addiction
• General studies
• Immunology
• Toxicology

Harlan Laboratories' Production

• We maintain on  Teklad Global Diet 2018S  within maximum security production facilities.