ACI Inbred Rat

Nomenclature: ACI/SegHsd

ACI Inbred Rat Origin

• The ACI inbred rat was derived from Columbia University, 1926 from an accidental mating between an August male with an Irish coat, and a Copenhagen 2331 Female. Derived from a nucleus colony obtained from Dr. A. Segaloff’s colony at the Ochsner Medical Center, Jefferson, Louisiana.

ACI Inbred Rat Characteristics

• Coat: Black Agouti, with white belly and feet
• Litter average:  6.0
• Haplotype:  RT1^av1
• Poor reproductive performance and low litter size due to high in-utero mortality 
• High incidence of congenital malformations including renal agenesis, hypoplasia, hydronephrosis or cystic kidney, unilateral, that may be associated with ipsilateral defective uterine horn or testis
• High incidence of testicular tumors 

 ACI Inbred Rat Research Use

• Estrogen-induced pituitary growth
• Carcinogenesis
• Transplant immunology

Harlan Laboratories' Production

• We maintain on Teklad Global 2018S within maximum security production barriers.