Athymic Nude Mutant Mice

 

 

Nomenclature:

  • US Stock:
    • Hsd:Athymic Nude-Foxn1nu
  • EU Stock:
    • Hsd:Athymic Nude-Foxn1nu
    • HsdCpb:NMRI-Foxn1nu
    • HsdHli:CD1-Foxn1nu
    • HsdOla:ICRF-Foxn1nu
    • HsdOla:MF1-Foxn1nu
  • EU Strain:
    • BALB/cOlaHsd-Foxn1nu

 

Related Genotypes:

  • Heterozygous Nomenclature:
    • Hsd:Athymic Nude-Foxn1nu/Foxn1+
    • BALB/cOlaHsd-Foxn1nu/Foxn1+
    • HsdCpb:NMRI-Foxn1nu/Foxn1+
    • HsdHli:CD-1-Foxn1nu/Foxn1+
    • HsdOla:MF1-Foxn1nu/Foxn1+
    • HsdOla:ICRF-Foxn1nu/Foxn1+

 

Information and Research Data
Click on Links Below
Health Monitoring and Global Availability
Athymic Nude Mice Data Sheet
Athymic Nude Mice European Data Sheet
Oncology Research Models Brochure
Cell Line Reference Table
U.S. Growth Curve
European Growth Curve Athymic nude
European Growth Curve NMRI nude

 Athymic Nude Mutant Mice Origin

  • US Stock:  This nude mouse was derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland. This immunodeficient model was originally thought to be a Balb/c congenic, but was later reported by NCI to be outbred.
  • EU Stock/Strain:  All models of this nude mouse were derived from a nucleus colony obtained from the Laboratory Animals Centre, Carshalton, which obtained the models from Institute of Animal Genetics, Edinburgh.

  Athymic Nude Mutant Mice Characteristics

  • Coat: Albino
  • Litter Average: 7
  • Foxn1nu autosomal recessive mutation on chromosome 11
  • Only homozygous mutants exhibit nu phenotype
  • Foxn1nu/Foxn1+ heterozygotes do not show partial expression of nu phenotype
  • Thymic aplasia
  • T-lymphocyte deficiency  
  • Normal B-lymphoctye function
  • Increased Natural Killer (NK) cell population
  • Phenotypically hairless (sparse, intermittent hair growth possible)

 Athymic Nude Mutant Mice Research Use

  • Oncology
  • Transplantation
  • Tumor cell growth
  • Immunology 

Harlan Laboratories' Production

References

1.  Gullino, P.M., Ediger, R.D., Giovanella, B., Merchant, B., Outzen, H.C., Reed, N.D. et al.  (1976).  Guide for the care and use of the nude (thymus-deficient) mouse in biomedical research.  Inst. Lab Animal Resources News, 19, 5-19.

2.  Fogh, J. and Giovanella, B. (Eds.).  (1978).  The Nude Mouse in Experimental and Clinical Research.  New York:  Academic Press.

3.  Committee on Immunologically Compromised Rodents, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council.  Immunodeficient Rodents: A Guide to Their Immunobiology, Husbandry, and Use.  National Academy Press, 1989.

 

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