Diabetic Mice

Nomenclature: BKS.Cg -+ Lepr^db/+ Lepr^db/OlaHsd

Related Genotypes (lean animals):          

• Heterozygous Nomenclature:     
  • BKS.Cg-m +/+ Lepr^db/OlaHsd (Black, Lean)
• Wild type Nomenclature:         
  • BKS.Cg-m +/m +/OlaHsd (Misty, Lean)

Our breeding scheme maintains m and Lepr^db in repulsion.
These genes are closely linked; however, recombination could occur. Our mice are most likely nonrecombinants, but they have not been tested.  Genetic testing is required to distinguish heterozygotes from wild type animals.
 

Diabetic Mice Origin

• The Diabetic mutant mouse originates from the Dunn Nutritional Laboratory, Cambridge, United Kingdom; to Olac, United Kingdom, in 1979; to Harlan, United States, in 2000.

Diabetic Mice Characteristics

• Coat: Black or misty
• Lepr^db is an autosomal recessive mutation on chromosome 4
• Exhibit obesity around 4-5 weeks of age
• Elevation of plasma insulin demonstrated at 10-14 days
• Hyperglycemia expressed at 4-8 weeks of age
• Polyphagia
• Proteinuria
• Glycosuria
• Polyuria/Polydipsia
• Hyperinsulinemia despite severe depletion of pancreatic islet insulin-producing B-cells
• Leptin receptor deficient

Diabetic Mice Research Use

• Diabetes, Type II
• Peripheral neuropathy
• Myocardial disease
• Immunodeficiency
• Immunology
• Metabolism
• Obesity

Harlan Laboratories' Production

• We maintain on Teklad Global Diet 2018S within maximum security production barrier facilities.