Fox Chase SCID®^ Beige Mutant Mice

Nomenclature: C.B-17/IcrHsd-Prkdc^scidLyst^bg

Fox Chase SCID Beige Mutant Mouse Origin

• Harlan acquired the Fox Chase SCID beige mutant mouse from the Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA in 1991.  

Fox Chase SCID Beige Mutant Mouse Characteristics

• Coat: Albino
• Severe combined immunodeficieny resulting from Prkdc^scid autosomal recessive, single nucleotide polymorphism on chromosome 16
• Lyst^bg autosomal recessive mutation on chromosome 13
• T-lymphocyte deficiency
• B-lymphocyte deficiency
• Diminished Natural Killer (NK) cell activity 
• Rudimentary thymus
• "Leaky" phenotype significantly suppressed relative to other SCID^® models
• Highly susceptible to opportunistic viral and bacterial infection

Fox Chase SCID Beige Mutant Mouse Research Use

• Oncology
• Teratology
• Transplantation
• Tumor cell growth
• Immunology

Harlan Laboratories' Production

We maintain on the following diets:

• US Stock:  Teklad Global Diet 2018S 
• EU Stock/Strain:  Teklad Global Diet 2019S 

Maintained within Harlan Isotec flexible-film isolators

FOX CHASE SCID^® is a registered trademard of Fox Chase Cancer Center, Philadelphia, Pennsylvania.