Athymic Nude Mutant Rat

Nomenclature

• US Stock: Hsd:RH-Foxn1^rnu
• EU Stock: HsdHan™:RNU-Foxn1^rnu

Related Genotypes:

• Heterozygous Nomenclature:
  • Hsd:RH-Foxn1^rnu/Foxn1⁺
  • HsdHan™:RNU-Foxn1^rnu/Foxn1⁺

Athymic Nude Mutant Rat Origin

• The Athymic nude mutant rat was derived from animals obtained from the Rowett Research Institute, Aberdeen, Scotland.

 Athymic Nude Mutant Rat Characteristics

• Coat:  Hooded (pigmented)
• Litter Average: 7
• Foxn1^rnu autosomal recessive mutation on chromosome 10
  • Only homozygous mutants exhibit rnu phenotype
  • Foxn1^rnu/Foxn1⁺heterozygotes do not show partial expression of rnu phenotype
• Thymic aplasia
• T-lymphocyte deficiency 
• Normal B-lymphocyte function
• Increased Natural Killer (NK) cell population
• Phenotypically hairless (sparse, intermittent hair growth possible)
•  

Athymic Nude Mutant Rat Research Use

• Oncology
• Immunology
• Imaging technology
• Xenograft transplantation

Harlan Laboratories' Production

• We maintain on the following diets: 
  • US Stock:  Teklad Global Diet 2018S  
  • EU Stock:  Teklad Global Diet 2019S 
• Maintained within Harlan Isotec flexible-film isolators

References

1. Vos, J.G., Kreeftenberg, J.G., Kruijt, B.C., Kruizinga, W. and Steerenberg, P. (1980).  The athymic nude rat:  Immunological characteristics.  Clinical immunology and Immunopathology, 15, 229-3.
2. Schuurman, H., Hougen, H.P. and Loveren, H.  (1992).  The rnu (Rowett Nude) and rnuN (nznu, New Zealand Nude) rat:  An update. ILAR, 34, 1-12.
3. Taubman, M.A., Ebersole, J.L. and Smith, D.J.  (1983).  Immunoglobulins of rnu/rnu ‘nude’ rats with congenital aplasia of the thymus. Immunology, 49, 295-300.
4. Suckow, M.A., Wiesbroth, S.H. and Franklin, C.L.  (Eds).  (2006).  The Laboratory Rat.  Amsterdam:  Elsevier Academic Press.