Nomenclature: HsdOla:DWARF-dw-4
Dwarf-4 Origin
This mutation arose in an inbred colony of LEW rats at Medical Research Council (Oxford). From Medical Research Council to Olac (now Harlan UK) in 1989.
Dwarf-4 Characteristics
- Coat: Albino
- Autosomal recessive dw-4 mutation causing a decrease in growth hormone (GH) from the pituitary gland
- Dwarfism is apparent at approximately 4-5 weeks of age
- Pituitary gland is often smaller in homozygous compared with heterozygous dwarfs
- Hormones LH and TSH produced by the pituitary are secreted normally
Dwarf-4 Research Use
Harlan Laboratories' Production
References
1. Charlton, H. M., R. G. Clark, I. C. A. F. Robinson, A. E. Porter Goff, B. S. Cox, C. Bugnon, and B. A. Bloch. (1988). Growth hormone-deficient dwarfism in the rat: a new mutation. J. Endocrinol. 119: 51-58.
2. Kamegai, J., T. G. Unterman, L. A. Frohman, and R. D. Kineman. (1998). Hypothalamic/Pituitary-Axis of the spontaneous dwarf rat: Autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid. Endocrinology. 139(8):3554-3560.
3. Hedrich HJ (1990) Mutant genes and polymorphic loci of the laboratory rat. In: Genetic monitoring of inbred strains of rats (Hedrich HJ, ed). Stuttgart, New York: Gustav Fischer Verlag, pp. 209- 409. - Available in print only, no online reference.
4. Sonntag, W. E. C. S. Carter, Y. Ikeno, K. Ekenstedt, C. S. Carlson, R. F. Loeser, S. Chakrabarty, S. Lee, C. Bennett, R. Ingram, T. Moore and M. Ramsey. (2005). Adult-Onset Growth Hormone and Insulin-Like Growth Factor I Deficiency Reduces Neoplastic Disease, Modifies Age-Related Pathology, and Increases Life Span. Endocrinology. 146(7):2920-2932.