Zucker Mutant Rat

Nomenclature:

• US Stock: HsdHlr:ZUCKER-Lepr^fa
• EU Stock: HsdOla:ZUCKER-Lepr^fa   

Additional Related Genotypes (lean animals):

• Heterozygous Nomenclature:
  • HsdHlr:ZUCKER-Lepr^fa/Lepr ⁺
  • HsdOla:ZUCKER-Lepr^fa/Lepr ⁺
• Wild Type Nomenclature:
  • HsdOla:ZUCKER-Lepr⁺
  • HsdHlr:ZUCKER-Lepr⁺
• Genetic testing is required to determine Lepr^fa/Lepr⁺ or Lepr⁺ genotype.

 Zucker Mutant Rat Origin

• HsdHlr:ZUCKER-Lepr^fa:This Zucker rat was derived from a colony obtained in 1992 from Hoffmann-La Roche, Nutley, New Jersey.

• HsdOla:ZUCKER-Lepr^fa: In 1980, this Zucker rat came from Wellcome Laboratories, Dartford to Olac (now Harlan UK).

Zucker Mutant Rat Characteristics

• Coat:  Black, brown, brown/white, black/white
• fa is an autosomal recessive mutation on chromosome 5
• Lepr^fa/Lepr⁺heterozygotes do not show partial expression of fa phenotype
• Animals have not been selectively bred to induce hyperglycemia
• Exhibit obesity at 4 to 5 weeks of age
• Insulin-resistant
• Hyperphagia
• Muscle atrophy
• Hyperlipemic
• Adipocyte hypertrophy and hyperplasia
• Hypercholesterolemia
• Hyperinsulinemia

Zucker Mutant Rat Research Use

• Genetic obesity
• Noninsulin-dependent diabetes mellitus

Harlan Laboratories' Production

• We maintain on Teklad Global Diet 2018S within maximum security production barrier facilities