• Eliminates maintenance of colonies to sustain available research models
• Reallocates production space and associated resources to other areas of research priority
• Preserves the genetic integrity of research models for future colony development
• Provides insurance against physical, genetic, and pathologic disasters
• Harvest of early stage embryos
• Number of embryos dependent upon client requirements
• Embryo storage in two geographically separate locations or returned to the client

• Embryo or hysterectomy rederivation from breeders obtained from the donating institution
• Health status evaluation using client-approved microbiologic monitoring profiles on foster or recipient females and/or offspring
• Eliminates pathogenic and opportunistic microorganisms
• Eliminates distribution restrictions to collaborating investigators
• Eliminates variables that affect research results
• Offspring delivered to the client or maintained by Harlan for colony expansion
  

• Maintenance in flexible-film isolators protects health and genetic integrity
• Custom breeding protocols
• Health status evaluation using client-approved microbiologic monitoring profiles
• Genetic monitoring and tissue sampling services
• Reallocates client production space and associated resources to other areas of research priority
• Delivery to clients in company-owned, environmentally-controlled vehicles
• Coordinates animal shipments to collaborating investigators

• Import coordination of domestic and international shipments
• Maintenance in flexible-film isolators protects health and genetic integrity
• Protocols designed for both breeding and nonbreeding quarantine procedures
• Health testing evaluation of sentinel or imported colony cohorts using client-approved microbiologic test profiles
• Genetic testing available
• Treatment of pathogens during quarantine
• Delivery to clients in company-owned, environment-controlled vehicles
• Eliminates clients’ risk of receiving pathogen-positive animals
• Protects health integrity of requesting institution from incoming animals
• Reallocates space, labor and other institutional resources
• Predefined or extended quarantine periods
• Distribution or production as required by requesting institution

Quarantine Animal Care and Husbandry

Cohorts of HsdBlu:LE rats, Hsd:Sprague Dawley®™ SD®™ rats, C57BL/6NHsd mice, and other stocks and strains of Harlan rodents, can be maintained on custom research diets within our production barriers.

The rodents are fed diets specified by the client for defined periods of time prior to shipment. Animals are shipped to the client using Harlan environment-controlled vehicles. Custom research diet animal maintenance on client-owned animals is also available.

Benefits of Harlan Custom Diet Animal Maintenance

• Harlan Teklad nutritionists, in collaboration with requesting investigators, customize the research diets to adjust nutrients and achieve experimental objectives
• Animals are maintained on client customized diets within Harlan maximum security production barriers until shipment
• Health and genetic integrity of the models are protected
• Reallocation of labor and other institutional resources
• Development of in-house diet maintenance protocols is eliminated
• The same diet can be fed after delivery to the client

Research Use:

• Obesity
• Diabetes mellitus
• Hypertension
• Hypercholesterolemia
• Osteoporosis
• Physiology
• Nutrition
• Pharmacology

Diet Induced Obesity (DIO) Rodent Models

• Harlan has developed standard protocols for raising DIO HsdBlu:LE rats and C57BL/6NHsd mice
• Randomly selected mice and rats are fed Harlan Teklad irradiated custom research diets until approximately 14 weeks of age
• Animals are provided ad libitum diet and water and weighed weekly

Please contact Technical Services at 1-(800)-793-7287 to discuss your specific custom research diet animal maintenance needs.

Other Rodent Services

• Research protocol performance
• Special matings including genetically modified and non-commercially available hybrids
• Superovulated or pseudopregnant mice
• Animal model development
• Custom animal aging
• Blood pressure monitoring
• Pristane-primed mice
• Animal identification (implantation, tagging, tattooing)
• Serum immunoglobulin IgG testing, i.e. scid mutant mouse models
• Export and import services